Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG)
نویسندگان
چکیده
منابع مشابه
A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization.
OBJECTIVE Genetic variants of cardiac ion channels may influence cardiac repolarization. Thereby such variants may modulate the penetrance of primary electrical disorders, contribute to differences in susceptibility to drug-induced QT-prolongation between individuals, or contribute to rhythm disturbances in the context of structural heart disease. Since the current encoded by KCNH2 (HERG; I(Kr)...
متن کاملMolecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.
Long QT syndrome (LQTS) is a cardiac repolarization disorder that can lead to arrhythmias and sudden death. Chromosome 7-linked inherited LQTS (LQT2) is caused by mutations in human ether-a-go-go-related gene (HERG; KCNH2), whereas drug-induced LQTS is caused primarily by HERG channel block. Many common polymorphisms are functionally silent and have been traditionally regarded as benign and wit...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2003
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(03)00458-9